Tert-butyl 4-oxoimidazolidine-1-carboxylate → HCID 71251980, compound

HRID 2411972Notes

Reaction equation

HRID 2411972 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:24]([O:28][C:29]([N:31]1[CH2:35][C:34](=[O:36])[NH:33][CH2:32]1)=[O:30])([CH3:27])([CH3:26])[CH3:25]>>[C:24]([O:28][C:29]([N:31]1[CH2:35][C:34](=[O:36])[N:33]([C:20]2[CH:21]=[CH:22][C:17]([C:15]([N:12]3[CH2:13][CH2:14][N:9]([C:3]4[C:2]([CH3:1])=[CH:7][C:6]([CH3:8])=[CH:5][N:4]=4)[CH2:10][CH2:11]3)=[O:16])=[CH:18][CH:19]=2)[CH2:32]1)=[O:30])([CH3:27])([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 4387212Tert-butyl 4-oxoimidazolidine-1-carboxylateHCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71251980HCID 71251980, compoundYield 87.7%

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (211 mg) described in Preparation Example 113 and 4-oxoimidazolidine-1-carboxylic acid tert-butyl ester (93 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (210 mg) was obtained.

Sources & evidence

ORD record
ord-95cbe7dcc21b42cc9245e9b85b3eee00
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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