Sodium Bicarbonate → HCID 71252560, compound

Participants

Reaction Steps

To 3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-oxoimidazolidine-1-carboxylic acid tert-butyl ester (200 mg) described in Example 634 were added methanol (3 mL) and 2N hydrogen chloride/methanol (1.05 mL), and the mixture was stirred at room temperature for 8 hr. To the reaction mixture was added aqueous sodium hydrogen carbonate solution, and the mixture was extracted with chloroform. The solvent was evaporated, and the residue was purified by column chromatography (ethyl acetate:methanol) to give the title compound (33 mg).

Provenance & Evidence