1,3-Propanesultam → HCID 71252325, compound

HRID 2411974Notes

Reaction equation

HRID 2411974 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH:23]4[CH2:25][CH2:24]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[S:26]1(=[O:32])(=[O:31])[CH2:30][CH2:29][CH2:28][NH:27]1>>[CH:23]1([C:19]2[CH:20]=[C:21]([CH3:22])[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[N:6]=[N:7][C:2]([N:27]5[CH2:28][CH2:29][CH2:30][S:26]5(=[O:32])=[O:31])=[CH:3][CH:4]=4)=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 86676768HCID 86676768, compound

Product 1

HCID 71252325HCID 71252325, compoundYield 39.8%

Procedure

Using (6-chloropyridazin-3-yl) [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (179 mg) described in Preparation Example 233 and isothiazolidine 1,1-dioxide (61 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (88 mg) was obtained.

Sources & evidence

ORD record
ord-aed50fb2d2ae42dfac4bbb0a92d030e7
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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