Water → HCID 71252908, compound

Participants

Reaction Steps

A mixture of 3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-4-one (48 mg) described in Example 635 and triethylamine (0.12 mL) was dissolved in tetrahydrofuran (1 mL), and methanesulfonyl chloride (15 μL) was added under ice-cooling. After stirring at room temperature for 8 hr, water was added to the reaction mixture, and the mixture was extracted with chloroform. The solvent was evaporated, and the residue was purified by column chromatography (ethyl acetate:hexane) to give the title compound (34 mg).

Provenance & Evidence