1-(Methylsulphonyl)imidazolidin-2-one → HCID 71252191, compound

HRID 2411980Notes

Reaction equation

HRID 2411980 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:24][S:25]([N:28]1[CH2:32][CH2:31][NH:30][C:29]1=[O:33])(=[O:27])=[O:26]>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[CH:3][C:2]([N:30]4[CH2:31][CH2:32][N:28]([S:25]([CH3:24])(=[O:27])=[O:26])[C:29]4=[O:33])=[N:7][CH:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 30162961-(Methylsulphonyl)imidazolidin-2-oneHCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252191HCID 71252191, compoundYield 74.2%

Procedure

Using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (188 mg) described in Preparation Example 127 and 1-methanesulfonylimidazolidin-2-one (82 mg) and by the reaction and treatment in the same manner as in Example 511, the title compound (170 mg) was obtained.

Sources & evidence

ORD record
ord-6c36fad78cb24f0d826126d3da534dea
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…