N,N-Dimethylurea → HCID 71252091, compound

HRID 2411989Notes

Reaction equation

HRID 2411989 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:24][N:25]([CH3:29])[C:26]([NH2:28])=[O:27]>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([NH:28][C:26](=[O:27])[N:25]([CH3:29])[CH3:24])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 11737N,N-DimethylureaHCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252091HCID 71252091, compoundYield 11.5%

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (211 mg) described in Preparation Example 113 and 1,1-dimethylurea (66 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (22 mg) was obtained.

Sources & evidence

ORD record
ord-69726f3c2a3a40049dd8b310df5d3912
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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