N-Acetylimidazolidinone → HCID 71252178, compound

HRID 2411990Notes

Reaction equation

HRID 2411990 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([N:24]2[CH2:28][CH2:27][CH2:26][S:25]2(=[O:30])=[O:29])[CH:3]=1.C([N:34]1[CH2:38][CH2:37][NH:36][C:35]1=[O:39])(=O)C>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:34]4[CH2:38][CH2:37][NH:36][C:35]4=[O:39])=[CH:3][C:4]=3[N:24]3[CH2:28][CH2:27][CH2:26][S:25]3(=[O:30])=[O:29])=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 79350N-AcetylimidazolidinoneHCID 58484716[4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252178HCID 71252178, compoundYield 16%

Procedure

Using [4-bromo-2-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (247 mg) described in Preparation Example 166 and 1-acetylimidazolidin-2-one (96 mg) and by the reaction and treatment in the same manner as in Example 638, the title compound (40 mg) was obtained.

Sources & evidence

ORD record
ord-3c8b99a659ea4a6ba578aa58c9fa20c3
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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