N,N-Dimethylurea → HCID 71252784, compound

HRID 2411993Notes

Reaction equation

HRID 2411993 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:24][N:25]([CH3:29])[C:26]([NH2:28])=[O:27]>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:28][C:26](=[O:27])[N:25]([CH3:29])[CH3:24])=[N:7][CH:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 11737N,N-DimethylureaHCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252784HCID 71252784, compoundYield 28.7%

Procedure

Using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (188 mg) described in Preparation Example 127 and 1,1-dimethylurea (66 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (55 mg) was obtained.

Sources & evidence

ORD record
ord-ae771fba91d24b2f937abb1023d8dc5d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…