1,3-Propanesultam → HCID 71252422, compound

HRID 2411997Notes

Reaction equation

HRID 2411997 reaction equation
C([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH:31]4[CH2:33][CH2:32]4)=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:34])(=O)C.[S:35]1(=[O:41])(=[O:40])[CH2:39][CH2:38][CH2:37][NH:36]1>>[CH:31]1([C:27]2[CH:28]=[C:29]([CH3:30])[C:24]([N:21]3[CH2:20][CH2:19][N:18]([C:16]([C:10]4[CH:11]=[CH:12][C:13]([N:36]5[CH2:37][CH2:38][CH2:39][S:35]5(=[O:41])=[O:40])=[CH:14][C:9]=4[N:6]4[CH2:7][CH2:8][NH:4][C:5]4=[O:34])=[O:17])[CH2:23][CH2:22]3)=[N:25][CH:26]=2)[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 58484546HCID 58484546, compound

Product 1

HCID 71252422HCID 71252422, compoundYield 28.4%

Procedure

Using 1-acetyl-3-{5-chloro-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one (152 mg) described in Preparation Example 236 and isothiazolidine 1,1-dioxide (57 mg) and by the reaction and treatment in the same manner as in Example 649, the title compound (47 mg) was obtained.

Sources & evidence

ORD record
ord-8a9d9d141f9f4b8cb5988d3845723a0f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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