HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylimidazolidin-2-one → [2,4-Bis(3-methyl-2-oxoimidazolidin-1-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylimidazolidin-2-one | HCID 567600 | — |
| Reactant | (2,4-Dibromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 71251897 | — |
| Product | [2,4-Bis(3-methyl-2-oxoimidazolidin-1-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 71252524 | 29.8% |
Reaction Steps
Using (2,4-dibromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (136 mg) described in Preparation Example 237 and 1-methylimidazolidin-2-one (90 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (44 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-4496a97bbcf1493998dae19535e768d1 |
| Source note | uspto-grants-2014_08 |