N,N',N'-Trimethylurea → HCID 71252090, compound

HRID 2411999Notes

Reaction equation

HRID 2411999 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:24][NH:25][C:26](=[O:30])[N:27]([CH3:29])[CH3:28]>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:25]([CH3:24])[C:26]([N:27]([CH3:29])[CH3:28])=[O:30])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 12435N,N',N'-TrimethylureaHCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252090HCID 71252090, compoundYield 64.1%

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (211 mg) described in Preparation Example 113 and trimethylurea (77 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (127 mg) was obtained.

Sources & evidence

ORD record
ord-c17e6a3260424096b7b51705df9ea77b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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