N-Acetylimidazolidinone → [2,4-Bis(2-oxoimidazolidin-1-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2412000Notes

Reaction equation

[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:26])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:23]=[CH:22][C:21](Br)=[CH:20][C:19]=4Br)=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.C([N:30]1[CH2:34][CH2:33][NH:32][C:31]1=[O:35])(=O)C>>[O:35]=[C:31]1[NH:32][CH2:33][CH2:34][N:30]1[C:19]1[CH:20]=[C:21]([N:32]2[CH2:33][CH2:34][NH:30][C:31]2=[O:35])[CH:22]=[CH:23][C:18]=1[C:16]([N:13]1[CH2:14][CH2:15][N:10]([C:7]2[C:6]([CH3:26])=[CH:5][C:4]([CH:1]3[CH2:3][CH2:2]3)=[CH:9][N:8]=2)[CH2:11][CH2:12]1)=[O:17]

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 71252039[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](2,4-dibromophenyl)methanone

Product 1

HCID 71252765[2,4-Bis(2-oxoimidazolidin-1-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 39.9%

Procedure

Using [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](2,4-dibromophenyl)methanone (250 mg) described in Preparation Example 238 and 1-acetylimidazolidin-2-one (200 mg) and by the reaction and treatment in the same manner as in Example 638, the title compound (102 mg) was obtained.

Sources & evidence

ORD record: ord-d227401fde4b435c93ff24e56b070723
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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