1-Methylimidazolidin-2-one → HCID 71252884, compound

HRID 2412003Notes

Reaction equation

HRID 2412003 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH:23]4[CH2:25][CH2:24]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([N:26]2[CH2:30][CH2:29][CH2:28][S:27]2(=[O:32])=[O:31])[CH:3]=1.[CH3:33][N:34]1[CH2:38][CH2:37][NH:36][C:35]1=[O:39]>>[CH:23]1([C:19]2[CH:20]=[C:21]([CH3:22])[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:36]5[CH2:37][CH2:38][N:34]([CH3:33])[C:35]5=[O:39])=[CH:3][C:4]=4[N:26]4[CH2:30][CH2:29][CH2:28][S:27]4(=[O:32])=[O:31])=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 58484554[4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252884HCID 71252884, compoundYield 65.4%

Procedure

Using [4-bromo-2-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (205 mg) described in Preparation Example 240 and 1-methylimidazolidin-2-one (59 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (139 mg) was obtained.

Sources & evidence

ORD record
ord-406a6e71a48743598e8f8f094e09380e
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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