HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanesultam → 1-[2-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]-3-methylimidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanesultam | HCID 642157 | — |
| Reactant | 1-{5-Chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidin-2-one | HCID 58484802 | — |
| Product | 1-[2-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]-3-methylimidazolidin-2-one | HCID 71253011 | 44.2% |
Reaction Steps
Using 1-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidin-2-one (85 mg) described in Preparation Example 241 and isothiazolidine 1,1-dioxide (36 mg) and by the reaction and treatment in the same manner as in Example 666, the title compound (45 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-b4cb8f3de6514a8d90525617592095fd |
| Source note | uspto-grants-2014_08 |