1,3-Propanesultam → HCID 71252617, compound

HRID 2412009Notes

Reaction equation

HRID 2412009 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH:30]4[CH2:32][CH2:31]4)=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[C:6]([N:8]2[CH2:12][CH2:11][N:10]([CH3:13])[C:9]2=[O:14])[CH:7]=1.[S:33]1(=[O:39])(=[O:38])[CH2:37][CH2:36][CH2:35][NH:34]1>>[CH:30]1([C:26]2[CH:27]=[C:28]([CH3:29])[C:23]([N:20]3[CH2:21][CH2:22][N:17]([C:15]([C:5]4[CH:4]=[CH:3][C:2]([N:34]5[CH2:35][CH2:36][CH2:37][S:33]5(=[O:39])=[O:38])=[CH:7][C:6]=4[N:8]4[CH2:12][CH2:11][N:10]([CH3:13])[C:9]4=[O:14])=[O:16])[CH2:18][CH2:19]3)=[N:24][CH:25]=2)[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 71252123HCID 71252123, compound

Product 1

HCID 71252617HCID 71252617, compoundYield 38.4%

Procedure

Using 1-{5-chloro-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidin-2-one (79 mg) described in Preparation Example 242 and isothiazolidine 1,1-dioxide (32 mg) and by the reaction and treatment in the same manner as in Example 666, the title compound (36 mg) was obtained.

Sources & evidence

ORD record
ord-8ea04c7a5d5c44fa95c8249a92505279
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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