2-Oxazolidinone → HCID 71251960, compound

HRID 2412010Notes

Reaction equation

Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[O:24]1[CH2:28][CH2:27][NH:26][C:25]1=[O:29]>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[N:6]=[N:7][C:2]([N:26]4[CH2:27][CH2:28][O:24][C:25]4=[O:29])=[CH:3][CH:4]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

Reactant 2

HCID 739492-Oxazolidinone

HCID 86676766HCID 86676766, compound

Product 1

HCID 71251960HCID 71251960, compoundYield 25.1%

Procedure

Using (6-chloropyridazin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (152 mg) described in Preparation Example 230 and oxazolidin-2-one (40 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (44 mg) was obtained.

Sources & evidence

ORD record: ord-3d154f355dbc4480b92e414df0739b9b
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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