5-Methyl-2-pyrrolidone → HCID 71252719, compound

HRID 2412017Notes

Reaction equation

HRID 2412017 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:24][CH:25]1[NH:29][C:28](=[O:30])[CH2:27][CH2:26]1>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[N:6]=[N:7][C:2]([N:29]4[CH:25]([CH3:24])[CH2:26][CH2:27][C:28]4=[O:30])=[CH:3][CH:4]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 86676766HCID 86676766, compound

Product 1

HCID 71252719HCID 71252719, compoundYield 10.1%

Procedure

Using (6-chloropyridazin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 230 and 5-methylpyrrolidin-2-one (54 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (18 mg) was obtained.

Sources & evidence

ORD record
ord-bb0961b14cb842e18cf8db3a2b3f7c6d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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