N-Acetylimidazolidinone → HCID 71251893, compound

HRID 2412020Notes

Reaction equation

Br[C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH:23]4[CH2:25][CH2:24]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1.C([N:29]1[CH2:33][CH2:32][NH:31][C:30]1=[O:34])(=O)C>>[CH:23]1([C:19]2[CH:20]=[C:21]([CH3:22])[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[N:6]=[CH:7][C:2]([N:29]5[CH2:33][CH2:32][NH:31][C:30]5=[O:34])=[N:3][CH:4]=4)=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=2)[CH2:25][CH2:24]1

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 86676769HCID 86676769, compound

Product 1

HCID 71251893HCID 71251893, compoundYield 51.3%

Procedure

Using (5-bromopyrazin-2-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 243 and 1-acetylimidazolidin-2-one (72 mg) and by the reaction and treatment in the same manner as in Example 638, the title compound (78 mg) was obtained.

Sources & evidence

ORD record: ord-86f763fb43d049ea820b3a4d3b0a3216
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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