(4R)-4-ethyl-1,3-oxazolidin-2-one → HCID 71252283, compound

HRID 2412023Notes

Reaction equation

HRID 2412023 reaction equation
Br[C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH:23]4[CH2:25][CH2:24]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1.[CH2:26]([C@@H:28]1[CH2:32][O:31][C:30](=[O:33])[NH:29]1)[CH3:27]>>[CH:23]1([C:19]2[CH:20]=[C:21]([CH3:22])[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[N:6]=[CH:7][C:2]([N:29]5[C@H:28]([CH2:26][CH3:27])[CH2:32][O:31][C:30]5=[O:33])=[N:3][CH:4]=4)=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 641503(4R)-4-ethyl-1,3-oxazolidin-2-oneHCID 86676769HCID 86676769, compound

Product 1

HCID 71252283HCID 71252283, compoundYield 31.5%

Procedure

Using (5-bromopyrazin-2-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (158 mg) described in Preparation Example 243 and (R)-4-ethyloxazolidin-2-one (68 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (54 mg) was obtained.

Sources & evidence

ORD record
ord-fdc4f957cf414142ac8c53a58e4d9962
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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