5-Methyl-2-pyrrolidone → HCID 71251986, compound

HRID 2412025Notes

Reaction equation

HRID 2412025 reaction equation
Br[C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH:23]4[CH2:25][CH2:24]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1.[CH3:26][CH:27]1[NH:31][C:30](=[O:32])[CH2:29][CH2:28]1>>[CH:23]1([C:19]2[CH:20]=[C:21]([CH3:22])[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[N:6]=[CH:7][C:2]([N:31]5[CH:27]([CH3:26])[CH2:28][CH2:29][C:30]5=[O:32])=[N:3][CH:4]=4)=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 86676769HCID 86676769, compound

Product 1

HCID 71251986HCID 71251986, compoundYield 26.8%

Procedure

Using (5-bromopyrazin-2-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 243 and 5-methylpyrrolidin-2-one (44 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (42 mg) was obtained.

Sources & evidence

ORD record
ord-3f3665ad9f784ae6afd6f4506441a992
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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