(R)-4-Methyloxazolidin-2-one → HCID 71252927, compound

HRID 2412027Notes

Reaction equation

HRID 2412027 reaction equation
Br[C:2]1[S:6][CH:5]=[C:4]([C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][N:16]=3)[CH2:11][CH2:10]2)=[O:8])[CH:3]=1.[CH3:23][C@@H:24]1[CH2:28][O:27][C:26](=[O:29])[NH:25]1>>[CH3:21][C:20]1[C:15]([N:12]2[CH2:13][CH2:14][N:9]([C:7]([C:4]3[CH:3]=[C:2]([N:25]4[C@H:24]([CH3:23])[CH2:28][O:27][C:26]4=[O:29])[S:6][CH:5]=3)=[O:8])[CH2:10][CH2:11]2)=[N:16][CH:17]=[C:18]([CH3:22])[CH:19]=1

Participants

3

Reactant 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 71252690HCID 71252690, compound

Product 1

HCID 71252927HCID 71252927, compoundYield 57.7%

Procedure

Using (5-bromothiophen-3-yl) [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (107 mg) described in Preparation Example 244 and (R)-4-methyloxazolidin-2-one (34 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (65 mg) was obtained.

Sources & evidence

ORD record
ord-4b0b600ec2c04bb4942a36fd555edf87
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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