1-Methylimidazolidin-2-one → HCID 71251919, compound

HRID 2412032Notes

Reaction equation

HRID 2412032 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:25][N:26]1[CH2:30][CH2:29][NH:28][C:27]1=[O:31]>>[CH3:25][N:26]1[CH2:30][CH2:29][N:28]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([N:10]3[CH2:15][CH2:14][N:13]([C:16]4[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=4)[CH2:12][CH2:11]3)=[O:9])=[CH:4][CH:3]=2)[C:27]1=[O:31]

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 58484793(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71251919HCID 71251919, compoundYield 90.6%

Procedure

Using (4-iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (435 mg) described in Preparation Example 120 and 1-methylimidazolidin-2-one (120 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (369 mg) was obtained.

Sources & evidence

ORD record
ord-edcaa24684bc4c2ba34dc462da516c1b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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