N-Acetylimidazolidinone → HCID 71253184, compound

HRID 2412038Notes

Reaction equation

HRID 2412038 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[F:24].[C:25]([N:28]1[CH2:32][CH2:31][NH:30][C:29]1=[O:33])(=O)C>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:30]4[CH2:31][CH2:32][N:28]([CH3:25])[C:29]4=[O:33])=[C:3]([F:24])[CH:4]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 79350N-AcetylimidazolidinoneHCID 58484572(4-Bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71253184HCID 71253184, compoundYield 72.5%

Procedure

Using (4-bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (839 mg) described in Preparation Example 125 and 1-acetylimidazolidin-2-one (329 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (638 mg) was obtained.

Sources & evidence

ORD record
ord-37cc3be59b254fd1b709a362fa72a997
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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