N-Acetylimidazolidinone → HCID 71252237, compound

HRID 2412040Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([CH:24]4[CH2:26][CH2:25]4)=[CH:22][C:21]([CH:27]4[CH2:29][CH2:28]4)=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[C:30]([N:33]1[CH2:37][CH2:36][NH:35][C:34]1=[O:38])(=[O:32])[CH3:31]>>[C:30]([N:33]1[CH2:37][CH2:36][N:35]([C:2]2[CH:3]=[CH:4][C:5]([C:10]([N:12]3[CH2:17][CH2:16][N:15]([C:18]4[C:23]([CH:24]5[CH2:26][CH2:25]5)=[CH:22][C:21]([CH:27]5[CH2:29][CH2:28]5)=[CH:20][N:19]=4)[CH2:14][CH2:13]3)=[O:11])=[C:6]([CH:9]=2)[C:7]#[N:8])[C:34]1=[O:38])(=[O:32])[CH3:31]

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 71252294HCID 71252294, compound

Product 1

HCID 71252237HCID 71252237, compoundYield 47.1%

Procedure

Using 5-bromo-2-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (1.35 g) described in Preparation Example 245 and 1-acetylimidazolidin-2-one (461 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (702 mg) was obtained.

Sources & evidence

ORD record: ord-114857fb1b4647bb9ec6ba170de53ef4
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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