1,3-Propanesultam → HCID 71252658, compound

HRID 2412042Notes

Reaction equation

HRID 2412042 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([CH:24]4[CH2:26][CH2:25]4)=[CH:22][C:21]([CH:27]4[CH2:29][CH2:28]4)=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[S:30]1(=[O:36])(=[O:35])[CH2:34][CH2:33][CH2:32][NH:31]1>>[CH:24]1([C:23]2[C:18]([N:15]3[CH2:16][CH2:17][N:12]([C:10]([C:5]4[CH:4]=[CH:3][C:2]([N:31]5[CH2:32][CH2:33][CH2:34][S:30]5(=[O:36])=[O:35])=[CH:9][C:6]=4[C:7]#[N:8])=[O:11])[CH2:13][CH2:14]3)=[N:19][CH:20]=[C:21]([CH:27]3[CH2:29][CH2:28]3)[CH:22]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 71252294HCID 71252294, compound

Product 1

HCID 71252658HCID 71252658, compoundYield 90.2%

Procedure

Using 5-bromo-2-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (451 mg) described in Preparation Example 245 and isothiazolidine 1,1-dioxide (158 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (443 mg) was obtained.

Sources & evidence

ORD record
ord-7d6f022b0bfb47e98ca47da0f5b5ff5a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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