N-Acetylimidazolidinone → HCID 71251896, compound

HRID 2412045Notes

Reaction equation

[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[C:28]([N:31]1[CH2:35][CH2:34][NH:33][C:32]1=[O:36])(=[O:30])[CH3:29]>>[C:28]([N:31]1[CH2:35][CH2:34][N:33]([C:24]2[CH:25]=[CH:26][C:21]([C:19]([N:16]3[CH2:15][CH2:14][N:13]([C:5]4[C:4]([CH:1]5[CH2:3][CH2:2]5)=[CH:9][C:8]([CH:10]5[CH2:11][CH2:12]5)=[CH:7][N:6]=4)[CH2:18][CH2:17]3)=[O:20])=[CH:22][CH:23]=2)[C:32]1=[O:36])(=[O:30])[CH3:29]

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71251896HCID 71251896, compoundYield 85%

Procedure

Using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (1.34 g) described in Preparation Example 186 and 1-acetylimidazolidin-2-one (461 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (1.14 g) was obtained.

Sources & evidence

ORD record: ord-d6b1c1de7ee6441f851fd78bde97e427
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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