1-Methylimidazolidin-2-one → HCID 71252928, compound

HRID 2412054Notes

Reaction equation

HRID 2412054 reaction equation
Br[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[CH:4][CH:3]=1.[CH3:25][N:26]1[CH2:30][CH2:29][NH:28][C:27]1=[O:31]>>[CH3:23][C:22]1[C:17]([N:14]2[CH2:15][CH2:16][N:11]([C:9]([C:5]3[CH:4]=[CH:3][C:2]([N:28]4[CH2:29][CH2:30][N:26]([CH3:25])[C:27]4=[O:31])=[N:7][C:6]=3[CH3:8])=[O:10])[CH2:12][CH2:13]2)=[N:18][CH:19]=[C:20]([CH3:24])[CH:21]=1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 71577776HCID 71577776, compound

Product 1

HCID 71252928HCID 71252928, compoundYield 77.4%

Procedure

Using (6-bromo-2-methylpyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (234 mg) described in Preparation Example 247 and 1-methylimidazolidin-2-one (72 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (190 mg) was obtained.

Sources & evidence

ORD record
ord-421d771f2e1743968784ba9ce23dade4
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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