1-Methylimidazolidin-2-one → HCID 71252395, compound

HRID 2412056Notes

Reaction equation

HRID 2412056 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:24])[C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[CH3:25][N:26]1[CH2:30][CH2:29][NH:28][C:27]1=[O:31]>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:24])[C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:28]4[CH2:29][CH2:30][N:26]([CH3:25])[C:27]4=[O:31])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 58484605[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252395HCID 71252395, compoundYield 85.3%

Procedure

Using [4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (348 mg) described in Preparation Example 133 and 1-methylimidazolidin-2-one (96 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (278 mg) was obtained.

Sources & evidence

ORD record
ord-cef54eb9addf40a88643a0ab91bf4650
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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