2-Pyrrolidone → HCID 71252378, compound

HRID 2412059Notes

Reaction equation

HRID 2412059 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:24])[C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[NH:25]1[CH2:29][CH2:28][CH2:27][C:26]1=[O:30]>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:24])[C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:25]4[CH2:29][CH2:28][CH2:27][C:26]4=[O:30])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484605[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252378HCID 71252378, compound

Procedure

Using [4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (435 mg) described in Preparation Example 133 and pyrrolidin-2-one (115 μL) and by the reaction and treatment in the same manner as in Example 262, the title compound (234 mg) was obtained.

Sources & evidence

ORD record
ord-cd90a6750ead4f1fa75a118042cf1afd
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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