1-Methylimidazolidin-2-one → HCID 71252040, compound

HRID 2412061Notes

Reaction equation

HRID 2412061 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH2:25][CH3:26])=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[CH3:27][N:28]1[CH2:32][CH2:31][NH:30][C:29]1=[O:33]>>[CH2:25]([C:21]1[CH:22]=[C:23]([CH3:24])[C:18]([N:15]2[CH2:16][CH2:17][N:12]([C:10]([C:5]3[CH:4]=[CH:3][C:2]([N:30]4[CH2:31][CH2:32][N:28]([CH3:27])[C:29]4=[O:33])=[CH:9][C:6]=3[C:7]#[N:8])=[O:11])[CH2:13][CH2:14]2)=[N:19][CH:20]=1)[CH3:26]

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 71252298HCID 71252298, compound

Product 1

HCID 71252040HCID 71252040, compoundYield 85.7%

Procedure

Using 5-bromo-2-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (827 mg) described in Preparation Example 246 and 1-methylimidazolidin-2-one (240 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (742 mg) was obtained.

Sources & evidence

ORD record
ord-07bfe12494664630be667d4ff901b2c6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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