HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanesultam → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylphenyl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanesultam | HCID 642157 | — |
| Reactant | (4-Bromo-2-methanesulfonylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484608 | — |
| Product | [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylphenyl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 71252950 | 54.1% |
Reaction Steps
Using (4-bromo-2-methanesulfonylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (466 mg) described in Preparation Example 254 and isothiazolidine 1,1-dioxide (158 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (274 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-a942a899dc2546e388154b2f3ea3857c |
| Source note | uspto-grants-2014_08 |