1-Methylimidazolidin-2-one → 1-{4-[4-(5-Ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-3-methylimidazolidin-2-one

HRID 2412077Notes

Reaction equation

HRID 2412077 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH2:23][CH3:24])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:25]([CH3:28])(=[O:27])=[O:26])[CH:3]=1.[CH3:29][N:30]1[CH2:34][CH2:33][NH:32][C:31]1=[O:35]>>[CH2:23]([C:19]1[CH:20]=[C:21]([CH3:22])[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:32]4[CH2:33][CH2:34][N:30]([CH3:29])[C:31]4=[O:35])=[CH:3][C:4]=3[S:25]([CH3:28])(=[O:27])=[O:26])=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=1)[CH3:24]

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 58484608(4-Bromo-2-methanesulfonylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 712522801-{4-[4-(5-Ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-3-methylimidazolidin-2-oneYield 84.9%

Procedure

Using (4-bromo-2-methanesulfonylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (466 mg) described in Preparation Example 254 and 1-methylimidazolidin-2-one (120 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (412 mg) was obtained.

Sources & evidence

ORD record
ord-06faa158d8db4d69865b62b7423c9c0a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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