HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Butanesultam → [4-(1,1-Dioxo-1lambda6-[1,2]thiazinan-2-yl)-2-methanesulfonylphenyl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Butanesultam | HCID 303508 | — |
| Reactant | (4-Bromo-2-methanesulfonylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484608 | — |
| Product | [4-(1,1-Dioxo-1lambda6-[1,2]thiazinan-2-yl)-2-methanesulfonylphenyl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 71252680 | 81.6% |
Reaction Steps
Using (4-bromo-2-methanesulfonylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (271 mg) described in Preparation Example 254 and [1,2]thiazinane 1,1-dioxide (102 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (247 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-89b11c406a5b4b4885e558e3a765c25c |
| Source note | uspto-grants-2014_08 |