2-Pyrrolidone → HCID 71252664, compound

HRID 2412080Notes

Reaction equation

Br[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[C:19]([CH3:25])[N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[CH:4][CH:3]=1.[NH:26]1[CH2:30][CH2:29][CH2:28][C:27]1=[O:31]>>[CH3:8][C:6]1[N:7]=[C:2]([N:26]2[CH2:30][CH2:29][CH2:28][C:27]2=[O:31])[CH:3]=[CH:4][C:5]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[C:19]([CH3:25])[N:18]=2)[CH2:13][CH2:12]1)=[O:10]

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 86676770HCID 86676770, compound

Product 1

HCID 71252664HCID 71252664, compound

Procedure

Using (6-bromo-2-methylpyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl) piperazin-1-yl]methanone (145 mg) described in Preparation Example 248 and pyrrolidin-2-one (41 μL) and by the reaction and treatment in the same manner as in Example 262, the title compound (148 mg) was obtained.

Sources & evidence

ORD record: ord-47499121a2b74196919e8335090285fa
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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