5-Methyl-2-pyrrolidone → HCID 71252078, compound

HRID 2412082Notes

Reaction equation

HRID 2412082 reaction equation
Br[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[C:19]([CH3:25])[N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[CH:4][CH:3]=1.[CH3:26][CH:27]1[NH:31][C:30](=[O:32])[CH2:29][CH2:28]1>>[CH3:26][CH:27]1[N:31]([C:2]2[CH:3]=[CH:4][C:5]([C:9]([N:11]3[CH2:16][CH2:15][N:14]([C:17]4[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[C:19]([CH3:25])[N:18]=4)[CH2:13][CH2:12]3)=[O:10])=[C:6]([CH3:8])[N:7]=2)[C:30](=[O:32])[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 86676770HCID 86676770, compound

Product 1

HCID 71252078HCID 71252078, compoundYield 85.8%

Procedure

Using (6-bromo-2-methylpyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (145 mg) described in Preparation Example 248 and 5-methylpyrrolidin-2-one (54 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (130 mg) was obtained.

Sources & evidence

ORD record
ord-c9ce3dcd1c664511869a7db1e7fdf0d2
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…