HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-2-pyrrolidone → 1-{5-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-6-methylpyridin-2-yl}-5-methylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-2-pyrrolidone | HCID 66055 | — |
| Reactant | (6-Bromo-2-methylpyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 86676771 | — |
| Product | 1-{5-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-6-methylpyridin-2-yl}-5-methylpyrrolidin-2-one | HCID 71252219 | 88.1% |
Reaction Steps
Using (6-bromo-2-methylpyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 249 and 5-methylpyrrolidin-2-one (54 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (138 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-e3effe8359584a55ac5c04ccfb2aa540 |
| Source note | uspto-grants-2014_08 |