Morpholine → HCID 71252746, compound

HRID 2412092Notes

Reaction equation

C(O[C:6]([N:8](C(OC(C)(C)C)=O)[C:9](=[O:40])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:11]=1[C:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[C:36]([CH3:37])=[CH:35][C:34]([CH2:38][CH3:39])=[CH:33][N:32]=2)[CH2:27][CH2:26]1)=[O:24])=O)(C)(C)C.N1C[CH2:52][O:51][CH2:50][CH2:49]1>>[O:22]=[S:17]1(=[O:21])[CH2:18][CH2:19][CH2:20][N:16]1[C:14]1[CH:13]=[CH:12][C:11]([C:23]([N:25]2[CH2:30][CH2:29][N:28]([C:31]3[C:36]([CH3:37])=[CH:35][C:34]([CH2:38][CH3:39])=[CH:33][N:32]=3)[CH2:27][CH2:26]2)=[O:24])=[C:10]([C:9]([N:8]2[CH2:49][CH2:50][O:51][CH2:52][CH2:6]2)=[O:40])[CH:15]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 71252189HCID 71252189, compound

Product 1

HCID 71252746HCID 71252746, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-5-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzamide (249 mg) described in Example 785 and morpholine (39 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (58 mg) was obtained.

Sources & evidence

ORD record: ord-bfcc1df3494b4cb6af1844c08b6421f6
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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