1-(5-Ethyl-3-methylpyridin-2-yl)piperazine → HCID 71252562, compound

HRID 2412094Notes

Reaction equation

HRID 2412094 reaction equation
[CH3:1][C:2]1[N:10]=[C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH2:17]([C:19]1[CH:20]=[C:21]([CH3:31])[C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:23][CH:24]=1)[CH3:18]>>[CH2:17]([C:19]1[CH:20]=[C:21]([CH3:31])[C:22]([N:25]2[CH2:26][CH2:27][N:28]([C:4]([C:3]3[CH:7]=[CH:8][C:9]([N:11]4[CH2:15][CH2:14][CH2:13][C:12]4=[O:16])=[N:10][C:2]=3[CH3:1])=[O:6])[CH2:29][CH2:30]2)=[N:23][CH:24]=1)[CH3:18]

Participants

3

Reactant 2

HCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazineHCID 71252239HCID 71252239, compound

Product 1

HCID 71252562HCID 71252562, compound

Procedure

Using a crude product (0.605 mmol) of 2-methyl-6-(2-oxopyrrolidin-1-yl)nicotinic acid which is an intermediate described in Example 791, and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (124 mg) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Example 93, the title compound (4 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 81 and by the reaction and treatment in the same manner as in Example 93

Sources & evidence

ORD record
ord-a4ad415b2df64d97b257dcdb591f1b38
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…