5-Methyl-2-pyrrolidone → HCID 71252655, compound

HRID 2412097Notes

Reaction equation

HRID 2412097 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[C:6]([N:8]2[CH2:12][C:11](=[O:13])[N:10]([CH3:14])[C:9]2=[O:15])[CH:7]=1.[CH3:32][CH:33]1[NH:37][C:36](=[O:38])[CH2:35][CH2:34]1>>[CH3:30][C:29]1[C:24]([N:21]2[CH2:22][CH2:23][N:18]([C:16]([C:5]3[CH:4]=[CH:3][C:2]([N:37]4[C:36](=[O:38])[CH2:35][CH2:34][CH:33]4[CH3:32])=[CH:7][C:6]=3[N:8]3[CH2:12][C:11](=[O:13])[N:10]([CH3:14])[C:9]3=[O:15])=[O:17])[CH2:19][CH2:20]2)=[N:25][CH:26]=[C:27]([CH3:31])[CH:28]=1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 71253013HCID 71253013, compound

Product 1

HCID 71252655HCID 71252655, compoundYield 11.9%

Procedure

Using 1-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidine-2,4-dione (155 mg) described in Preparation Example 256 and 5-methylpyrrolidin-2-one (52 mg) and by the reaction and treatment in the same manner as in Example 666, the title compound (21 mg) was obtained.

Sources & evidence

ORD record
ord-3b3f8c830b58416c9bff557bc86ee22e
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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