HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Fluoro-2-methoxyphenyl)piperazine → [4-(4-Fluoro-2-methoxyphenyl)piperazin-1-yl][4-(imidazo[4,5-b]pyridin-3-yl)phenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Fluoro-2-methoxyphenyl)piperazine | HCID 10488654 | — |
| Reactant | Ethyl 4-(imidazo[4,5-b]pyridin-3-yl)benzoate | HCID 71252216 | — |
| Product | [4-(4-Fluoro-2-methoxyphenyl)piperazin-1-yl][4-(imidazo[4,5-b]pyridin-3-yl)phenyl]methanone | HCID 71252400 | 16.1% |
Reaction Steps
Using ethyl 4-(imidazo[4,5-b]pyridin-3-yl)benzoate (300 mg) described in Preparation Example 77 and 1-(4-fluoro-2-methoxyphenyl)piperazine (236 mg) and by the reaction and treatment in the same manner as in Example 170, the title compound (78 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-41e98ed98b504868a7a379e719d4609c |
| Source note | uspto-grants-2014_08 |