Caprolactam → HCID 71252963, compound

HRID 2412100Notes

Reaction equation

HRID 2412100 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1.[NH:24]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][C:25]1=[O:31]>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:24]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][C:25]3=[O:31])=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 7768CaprolactamHCID 58484733[4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252963HCID 71252963, compoundYield 76.3%

Procedure

Using [4-(2,4-dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone (205 mg) described in Preparation Example 108 and azepan-2-one (58 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (151 mg) was obtained.

Sources & evidence

ORD record
ord-f0136e0dd30e4d22a4eea8c6a1f70628
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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