Potassium Phosphate, Tribasic → HCID 71252555, compound

Participants

Reaction Steps

To a mixture of [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (270 mg) described in Preparation Example 113, palladium acetate (8 mg), 2-(dicyclohexylphosphino)biphenyl (22 mg), tripotassium phosphate (190 mg) and piperazine-1-carboxylic acid dimethylamide (111 mg) was added 1,2-dimethoxyethane (5 mL), and the mixture was stirred with heating under reflux for 7 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and the solvent was evaporated. The obtained residue was purified by NH coated silica gel column chromatography (ethyl acetate:hexane) to give the title compound (58 mg).

Provenance & Evidence