Cyclopentylamine → HCID 71251871, compound

HRID 2412102Notes

Reaction equation

C(OC([N:8](C(OC(C)(C)C)=O)[C:9](=[O:38])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH3:37])=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C.[CH:46]1(N)[CH2:50][CH2:49][CH2:48][CH2:47]1>>[CH:46]1([NH:8][C:9](=[O:38])[C:10]2[CH:15]=[C:14]([N:16]3[CH2:20][CH2:19][CH2:18][C:17]3=[O:21])[CH:13]=[CH:12][C:11]=2[C:22]([N:24]2[CH2:29][CH2:28][N:27]([C:30]3[C:35]([CH3:36])=[CH:34][C:33]([CH3:37])=[CH:32][N:31]=3)[CH2:26][CH2:25]2)=[O:23])[CH2:50][CH2:49][CH2:48][CH2:47]1

Participants

Reactant 2

HCID 2906Cyclopentylamine

HCID 71252805HCID 71252805, compound

Product 1

HCID 71251871HCID 71251871, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (187 mg) described in Example 769 and cyclopentylamine (36 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (87 mg) was obtained.

Sources & evidence

ORD record: ord-8831b97e2ba74525a19e513b10fb99f8
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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