Morpholine → HCID 71251968, compound

HRID 2412106Notes

Reaction equation

C(O[C:6]([N:8](C(OC(C)(C)C)=O)[C:9](=[O:41])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:11]=1[C:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[C:36]([CH3:37])=[CH:35][C:34]([CH:38]3[CH2:40][CH2:39]3)=[CH:33][N:32]=2)[CH2:27][CH2:26]1)=[O:24])=O)(C)(C)C.N1C[CH2:53][O:52][CH2:51][CH2:50]1>>[CH:38]1([C:34]2[CH:35]=[C:36]([CH3:37])[C:31]([N:28]3[CH2:29][CH2:30][N:25]([C:23]([C:11]4[CH:12]=[CH:13][C:14]([N:16]5[CH2:20][CH2:19][CH2:18][S:17]5(=[O:22])=[O:21])=[CH:15][C:10]=4[C:9]([N:8]4[CH2:50][CH2:51][O:52][CH2:53][CH2:6]4)=[O:41])=[O:24])[CH2:26][CH2:27]3)=[N:32][CH:33]=2)[CH2:40][CH2:39]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 71252685HCID 71252685, compound

Product 1

HCID 71251968HCID 71251968, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-5-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzamide (155 mg) described in Example 805 and morpholine (24 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (36 mg) was obtained.

Sources & evidence

ORD record: ord-79935865395c4b86893ffbfb59df4b89
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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