HCID 71252122, compound → HCID 71252016, compound

HRID 2412107Notes

Reaction equation

HRID 2412107 reaction equation
C(O[C:6]([N:8](C(OC(C)(C)C)=O)[C:9](=[O:39])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH2:37][CH3:38])=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C>O1CCCC1.CN>[CH2:37]([C:33]1[CH:34]=[C:35]([CH3:36])[C:30]([N:27]2[CH2:26][CH2:25][N:24]([C:22]([C:11]3[CH:12]=[CH:13][C:14]([N:16]4[CH2:20][CH2:19][CH2:18][C:17]4=[O:21])=[CH:15][C:10]=3[C:9]([NH:8][CH3:6])=[O:39])=[O:23])[CH2:29][CH2:28]2)=[N:31][CH:32]=1)[CH3:38]

Participants

3

Reactant 1

HCID 71252122HCID 71252122, compound

Product 1

HCID 71252016HCID 71252016, compoundYield 14.1%

Reagents, catalysts & solvents 1

HCID 66615946Methylamine tetrahydrofuranSolvent

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (70 mg) described in Example 809 and 2 mol/L methylamine tetrahydrofuran solution (220 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (7 mg) was obtained.

Sources & evidence

ORD record
ord-38bd49aee0a94ae8bc787a62257be965
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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