Dimethylamine tetrahydrofuran → HCID 71252157, compound

HRID 2412112Notes

Reaction equation

C(O[C:6]([N:8]([C:41](OC(C)(C)C)=O)[C:9](=[O:40])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH:37]3[CH2:39][CH2:38]3)=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C.O1CCCC1.CNC>>[CH:37]1([C:33]2[CH:34]=[C:35]([CH3:36])[C:30]([N:27]3[CH2:28][CH2:29][N:24]([C:22]([C:11]4[CH:12]=[CH:13][C:14]([N:16]5[CH2:20][CH2:19][CH2:18][C:17]5=[O:21])=[CH:15][C:10]=4[C:9]([N:8]([CH3:41])[CH3:6])=[O:40])=[O:23])[CH2:25][CH2:26]3)=[N:31][CH:32]=2)[CH2:38][CH2:39]1

Participants

Reactant 2

HCID 22320367Dimethylamine tetrahydrofuran

HCID 71252396HCID 71252396, compound

Product 1

HCID 71252157HCID 71252157, compoundYield 52.5%

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (70 mg) described in Example 814 and 2 mol/L dimethylamine tetrahydrofuran solution (216 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (27 mg) was obtained.

Sources & evidence

ORD record: ord-3923d73364f148f492c8bdef84e2ceae
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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