Morpholine → HCID 71252087, compound

HRID 2412114Notes

Reaction equation

C(OC(N(C(OC(C)(C)C)=O)[C:9](=[O:40])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH:37]3[CH2:39][CH2:38]3)=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C.[NH:48]1[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1>>[CH:37]1([C:33]2[CH:34]=[C:35]([CH3:36])[C:30]([N:27]3[CH2:26][CH2:25][N:24]([C:22]([C:11]4[CH:12]=[CH:13][C:14]([N:16]5[CH2:20][CH2:19][CH2:18][C:17]5=[O:21])=[CH:15][C:10]=4[C:9]([N:48]4[CH2:53][CH2:52][O:51][CH2:50][CH2:49]4)=[O:40])=[O:23])[CH2:29][CH2:28]3)=[N:31][CH:32]=2)[CH2:39][CH2:38]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 71252396HCID 71252396, compound

Product 1

HCID 71252087HCID 71252087, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (70 mg) described in Example 814 and morpholine (38 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (20 mg) was obtained.

Sources & evidence

ORD record: ord-6f490c4bac3944d8b8e22c3ad486f7e9
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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