2-Pyrrolidone → HCID 71252643, compound

HRID 2412115Notes

Reaction equation

Br[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH:23]4[CH2:25][CH2:24]4)=[CH:21][C:20]([CH:26]4[CH2:28][CH2:27]4)=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[CH:4][CH:3]=1.[NH:29]1[CH2:33][CH2:32][CH2:31][C:30]1=[O:34]>>[CH:23]1([C:22]2[C:17]([N:14]3[CH2:15][CH2:16][N:11]([C:9]([C:5]4[CH:4]=[CH:3][C:2]([N:29]5[CH2:33][CH2:32][CH2:31][C:30]5=[O:34])=[N:7][C:6]=4[CH3:8])=[O:10])[CH2:12][CH2:13]3)=[N:18][CH:19]=[C:20]([CH:26]3[CH2:28][CH2:27]3)[CH:21]=2)[CH2:25][CH2:24]1

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 86676773HCID 86676773, compound

Product 1

HCID 71252643HCID 71252643, compoundYield 103%

Procedure

Using (6-bromo-2-methylpyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (100 mg) described in Preparation Example 251 and pyrrolidin-2-one (29 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (104 mg) was obtained.

Sources & evidence

ORD record: ord-d207a160a9ea44db906f864af2b248d5
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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