5-Methyl-2-pyrrolidone → HCID 71252069, compound

HRID 2412116Notes

Reaction equation

HRID 2412116 reaction equation
Br[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH:23]4[CH2:25][CH2:24]4)=[CH:21][C:20]([CH:26]4[CH2:28][CH2:27]4)=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[CH:4][CH:3]=1.[CH3:29][CH:30]1[NH:34][C:33](=[O:35])[CH2:32][CH2:31]1>>[CH:23]1([C:22]2[C:17]([N:14]3[CH2:15][CH2:16][N:11]([C:9]([C:5]4[CH:4]=[CH:3][C:2]([N:34]5[CH:30]([CH3:29])[CH2:31][CH2:32][C:33]5=[O:35])=[N:7][C:6]=4[CH3:8])=[O:10])[CH2:12][CH2:13]3)=[N:18][CH:19]=[C:20]([CH:26]3[CH2:28][CH2:27]3)[CH:21]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 86676773HCID 86676773, compound

Product 1

HCID 71252069HCID 71252069, compoundYield 58.6%

Procedure

Using (6-bromo-2-methylpyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (100 mg) described in Preparation Example 251 and 5-methylpyrrolidin-2-one (34 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (61 mg) was obtained.

Sources & evidence

ORD record
ord-f19469a6de14414b864759f201013d04
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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