Propanenitrile, 3-(methylamino)- → HCID 71253156, compound

HRID 2412119Notes

Reaction equation

HRID 2412119 reaction equation
C(O[C:6]([N:8]([C:39](OC(C)(C)C)=O)[C:9](=[O:38])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH3:37])=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C.C[NH:47][CH2:48][CH2:49]C#N>>[C:48]([CH2:49][CH2:39][N:8]([CH3:6])[C:9](=[O:38])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH3:37])=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])#[N:47]

Participants

3

Reactant 2

HCID 69656Propanenitrile, 3-(methylamino)-HCID 71252805HCID 71252805, compound

Product 1

HCID 71253156HCID 71253156, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (150 mg) described in Example 769 and 3-methylaminopropionitrile (90 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (26 mg) was obtained.

Sources & evidence

ORD record
ord-d4c7200d5c4a4df7a3d6dc1a009a57ac
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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